| Team | Name | Symbol | Appearances | Wins | Saves | K'S | Losses | Walks/Hits | ER | Wins | Saves | K'S | Losses | Walks/Hits | ER |
| ARZ | Brandon Lyon | lyobr | 85 | 4 | 45 | 62 | 8 | 112 | 38 | 0.05 | 0.53 | 0.73 | 0.09 | 1.32 | 0.45 |
| ARZ | Jon Rauch | raujo | 85 | 5 | 25 | 81 | 5 | 83 | 29 | 0.06 | 0.29 | 0.95 | 0.06 | 0.98 | 0.34 |
| ATL | Jorge Julio | juljo | 85 | 2 | 25 | 85 | 2 | 165 | 63 | 0.02 | 0.29 | 1.00 | 0.02 | 1.94 | 0.74 |
| BAL | Chris Ray | raych | 85 | 5 | 32 | 87 | 8 | 105 | 42 | 0.06 | 0.38 | 1.02 | 0.09 | 1.24 | 0.49 |
| BAL | George Sherrill | shege | 85 | 5 | 50 | 87 | 8 | 121 | 41 | 0.06 | 0.59 | 1.02 | 0.09 | 1.42 | 0.48 |
| BOS | Jonathan Papelbon | papjo | 85 | 5 | 50 | 102 | 6 | 77 | 20 | 0.06 | 0.59 | 1.20 | 0.07 | 0.91 | 0.24 |
| CHC | Kerry Wood | wooke | 85 | 5 | 50 | 112 | 3 | 93 | 20 | 0.06 | 0.59 | 1.32 | 0.04 | 1.09 | 0.24 |
| CHW | Bobby Jenks | jenbo | 85 | 5 | 50 | 50 | 2 | 79 | 20 | 0.06 | 0.59 | 0.59 | 0.02 | 0.93 | 0.24 |
| CHW | Mike MacDougal | macmi | 85 | 3 | 25 | 67 | 7 | 122 | 43 | 0.04 | 0.29 | 0.79 | 0.08 | 1.44 | 0.51 |
| CIN | Francisco Cordero | corfr | 85 | 5 | 35 | 92 | 7 | 116 | 34 | 0.06 | 0.41 | 1.08 | 0.08 | 1.36 | 0.40 |
| CIN | David Weathers | weada | 85 | 4 | 25 | 59 | 8 | 123 | 30 | 0.05 | 0.29 | 0.69 | 0.09 | 1.45 | 0.35 |
| COL | Brian Fuentes | fuebr | 85 | 2 | 38 | 90 | 7 | 94 | 27 | 0.02 | 0.45 | 1.06 | 0.08 | 1.11 | 0.32 |
| DET | Todd Jones | jonto | 85 | 5 | 33 | 50 | 2 | 129 | 44 | 0.06 | 0.39 | 0.59 | 0.02 | 1.52 | 0.52 |
| FLA | Kevin Gregg | greke | 85 | 5 | 40 | 71 | 8 | 103 | 25 | 0.06 | 0.47 | 0.84 | 0.09 | 1.21 | 0.29 |
| HOU | LaTroy Hawkins | hawla | 85 | 5 | 25 | 71 | 3 | 133 | 54 | 0.06 | 0.29 | 0.84 | 0.04 | 1.56 | 0.64 |
| HOU | Jose Valverde | valvj | 85 | 5 | 46 | 95 | 5 | 108 | 40 | 0.06 | 0.54 | 1.12 | 0.06 | 1.27 | 0.47 |
| KAN | Joakim Soria | sorjo | 85 | 2 | 50 | 99 | 4 | 75 | 20 | 0.02 | 0.59 | 1.16 | 0.05 | 0.88 | 0.24 |
| LAA | Francisco Rodriguez | rodfr | 85 | 3 | 50 | 85 | 3 | 99 | 24 | 0.04 | 0.59 | 1.00 | 0.04 | 1.16 | 0.28 |
| LAD | Takashi Saito | saita | 85 | 5 | 38 | 116 | 7 | 101 | 22 | 0.06 | 0.45 | 1.36 | 0.08 | 1.19 | 0.26 |
| MIL | Eric Gagne | gager | 85 | 5 | 25 | 68 | 5 | 133 | 58 | 0.06 | 0.29 | 0.80 | 0.06 | 1.56 | 0.68 |
| MIL | Salomon Torres | torsa | 85 | 5 | 36 | 65 | 5 | 119 | 28 | 0.06 | 0.42 | 0.76 | 0.06 | 1.40 | 0.33 |
| MIL | Derrick Turnbow | turde | 85 | 5 | 25 | 103 | 6 | 96 | 36 | 0.06 | 0.29 | 1.21 | 0.07 | 1.13 | 0.42 |
| Team | Name | Symbol | Appearances | Wins | Saves | K'S | Losses | Walks/Hits | ER | Wins | Saves | K'S | Losses | Walks/Hits | ER |
| MIN | Eddie Guardado | guaed | 85 | 5 | 25 | 50 | 4 | 76 | 27 | 0.06 | 0.29 | 0.59 | 0.05 | 0.89 | 0.32 |
| MIN | Joe Nathan | natjo | 85 | 2 | 50 | 94 | 2 | 76 | 20 | 0.02 | 0.59 | 1.11 | 0.02 | 0.89 | 0.24 |
| NYM | Aaron Heilman | heiaa | 85 | 3 | 25 | 97 | 8 | 126 | 54 | 0.04 | 0.29 | 1.14 | 0.09 | 1.48 | 0.64 |
| NYM | Al Reyes | reyal | 85 | 5 | 25 | 63 | 7 | 102 | 36 | 0.06 | 0.29 | 0.74 | 0.08 | 1.20 | 0.42 |
| NYM | Billy Wagner | wagbi | 85 | 2 | 50 | 99 | 2 | 80 | 23 | 0.02 | 0.59 | 1.16 | 0.02 | 0.94 | 0.27 |
| NYY | Mariano Rivera | rivma | 85 | 5 | 48 | 109 | 8 | 70 | 20 | 0.06 | 0.56 | 1.28 | 0.09 | 0.82 | 0.24 |
| OAK | Huston Street | strhu | 85 | 5 | 32 | 89 | 8 | 124 | 46 | 0.06 | 0.38 | 1.05 | 0.09 | 1.46 | 0.54 |
| PHL | Tom Gordon | gorto | 85 | 5 | 25 | 65 | 8 | 121 | 43 | 0.06 | 0.29 | 0.76 | 0.09 | 1.42 | 0.51 |
| PHL | Brad Lidge | lidbr | 85 | 4 | 48 | 107 | 2 | 103 | 20 | 0.05 | 0.56 | 1.26 | 0.02 | 1.21 | 0.24 |
| PIT | Matt Capps | capma | 85 | 5 | 40 | 67 | 7 | 99 | 33 | 0.06 | 0.47 | 0.79 | 0.08 | 1.16 | 0.39 |
| SanD | Trevor Hoffman | hoftr | 85 | 3 | 50 | 88 | 8 | 90 | 39 | 0.04 | 0.59 | 1.04 | 0.09 | 1.06 | 0.46 |
| SanF | Brian Wilson | wilsb | 85 | 2 | 50 | 87 | 4 | 119 | 38 | 0.02 | 0.59 | 1.02 | 0.05 | 1.40 | 0.45 |
| SEA | J.J. Putz | putjj | 85 | 5 | 25 | 99 | 8 | 162 | 42 | 0.06 | 0.29 | 1.16 | 0.09 | 1.91 | 0.49 |
| SLC | Jason Isringhausen | isrja | 85 | 3 | 25 | 73 | 8 | 142 | 55 | 0.04 | 0.29 | 0.86 | 0.09 | 1.67 | 0.65 |
| TAM | Troy Percival | pertr | 85 | 5 | 50 | 75 | 2 | 83 | 34 | 0.06 | 0.59 | 0.88 | 0.02 | 0.98 | 0.40 |
| TAM | Dan Wheeler | wheda | 85 | 4 | 25 | 57 | 8 | 84 | 25 | 0.05 | 0.29 | 0.67 | 0.09 | 0.99 | 0.29 |
| TEX | C.J. Wilson | wilcj | 85 | 4 | 41 | 70 | 4 | 130 | 53 | 0.05 | 0.48 | 0.82 | 0.05 | 1.53 | 0.62 |
| TOR | Armando Benitez | benar | 85 | 4 | 25 | 84 | 8 | 118 | 43 | 0.05 | 0.29 | 0.99 | 0.09 | 1.39 | 0.51 |
| TOR | B.J. Ryan | ryabj | 85 | 4 | 45 | 76 | 8 | 109 | 28 | 0.05 | 0.53 | 0.89 | 0.09 | 1.28 | 0.33 |
| WSH | Chad Cordero | corch | 85 | 3 | 39 | 62 | 5 | 113 | 32 | 0.04 | 0.46 | 0.73 | 0.06 | 1.33 | 0.38 |