| Team | Name | Symbol | Appearances | R Yds | R TDs | Rec | R Yds | R TD's | Fum L | R Yds | R TDs | Rec | R Yds | R TD's | Fum L |
| ARZ | Tim Hightower | higti | 16 | 566 | 10 | 75 | 600 | 2 | 4 | 35.38 | 0.63 | 4.69 | 37.50 | 0.13 | 0.25 |
| ARZ | Beanie Wells | welbe | 16 | 750 | 5 | 15 | 150 | 2 | 2 | 46.88 | 0.31 | 0.94 | 9.38 | 0.13 | 0.13 |
| ATL | Jerious Norwood | norje | 16 | 500 | 4 | 36 | 338 | 2 | 2 | 31.25 | 0.25 | 2.25 | 21.13 | 0.13 | 0.13 |
| ATL | Michael Turner | turmi | 16 | 1440 | 20 | 10 | 100 | 2 | 4 | 90.00 | 1.25 | 0.63 | 6.25 | 0.13 | 0.25 |
| BAL | Le'Ron McClain | mccle | 16 | 500 | 2 | 32 | 229 | 2 | 2 | 31.25 | 0.13 | 2.00 | 14.31 | 0.13 | 0.13 |
| BAL | Willis McGahee | mcgaw | 16 | 500 | 11 | 21 | 142 | 5 | 2 | 31.25 | 0.69 | 1.31 | 8.88 | 0.31 | 0.13 |
| BAL | Ray Rice | ricra | 16 | 1146 | 10 | 75 | 600 | 2 | 2 | 71.63 | 0.63 | 4.69 | 37.50 | 0.13 | 0.13 |
| BUF | Fred Jackson | jacfr | 16 | 890 | 2 | 40 | 354 | 2 | 2 | 55.63 | 0.13 | 2.50 | 22.13 | 0.13 | 0.13 |
| BUF | Marshawn Lynch | lynma | 16 | 694 | 3 | 54 | 394 | 2 | 2 | 43.38 | 0.19 | 3.38 | 24.63 | 0.13 | 0.13 |
| CAR | Jonathan Stewart | stejo | 16 | 768 | 8 | 26 | 206 | 2 | 4 | 48.00 | 0.50 | 1.63 | 12.88 | 0.13 | 0.25 |
| CAR | DeAngelo Williams | widea | 16 | 1536 | 14 | 40 | 370 | 2 | 5 | 96.00 | 0.88 | 2.50 | 23.13 | 0.13 | 0.31 |
| CHI | Matt Forte | forma | 16 | 882 | 6 | 60 | 518 | 2 | 2 | 55.13 | 0.38 | 3.75 | 32.38 | 0.13 | 0.13 |
| CHI | Kevin Jones | jonke | 16 | 500 | 2 | 10 | 100 | 2 | 2 | 31.25 | 0.13 | 0.63 | 6.25 | 0.13 | 0.13 |
| CIN | Cedric Benson | bence | 16 | 1674 | 12 | 20 | 132 | 2 | 2 | 104.63 | 0.75 | 1.25 | 8.25 | 0.13 | 0.13 |
| CIN | Larry Johnson | johla | 16 | 818 | 2 | 27 | 174 | 2 | 2 | 51.13 | 0.13 | 1.69 | 10.88 | 0.13 | 0.13 |
| CLV | Jamal Lewis | lewja | 16 | 931 | 2 | 16 | 187 | 2 | 2 | 58.19 | 0.13 | 1.00 | 11.69 | 0.13 | 0.13 |
| DAL | Marion Barber | barma | 16 | 1022 | 9 | 21 | 176 | 2 | 2 | 63.88 | 0.56 | 1.31 | 11.00 | 0.13 | 0.13 |
| DAL | Felix Jones | jonfe | 16 | 795 | 3 | 11 | 149 | 2 | 5 | 49.69 | 0.19 | 0.69 | 9.31 | 0.13 | 0.31 |
| DEN | Correll Buckhalter | bucco | 16 | 807 | 2 | 46 | 363 | 2 | 2 | 50.44 | 0.13 | 2.88 | 22.69 | 0.13 | 0.13 |
| DEN | LaMont Jordan | jorla | 16 | 500 | 2 | 10 | 100 | 2 | 2 | 31.25 | 0.13 | 0.63 | 6.25 | 0.13 | 0.13 |
| DEN | Knowshon Moreno | morkn | 16 | 846 | 4 | 22 | 128 | 2 | 5 | 52.88 | 0.25 | 1.38 | 8.00 | 0.13 | 0.31 |
| DET | Kevin Smith | smike | 16 | 920 | 6 | 50 | 402 | 2 | 2 | 57.50 | 0.38 | 3.13 | 25.13 | 0.13 | 0.13 |
| GBP | Ryan Grant | grary | 16 | 1242 | 8 | 32 | 248 | 2 | 2 | 77.63 | 0.50 | 2.00 | 15.50 | 0.13 | 0.13 |
| Team | Name | Symbol | Appearances | R Yds | R TDs | Rec | R Yds | R TD's | Fum L | R Yds | R TDs | Rec | R Yds | R TD's | Fum L |
| HOU | Chris Brown | broch | 16 | 500 | 2 | 11 | 100 | 2 | 2 | 31.25 | 0.13 | 0.69 | 6.25 | 0.13 | 0.13 |
| HOU | Steve Slaton | slast | 16 | 638 | 5 | 57 | 580 | 5 | 5 | 39.88 | 0.31 | 3.56 | 36.25 | 0.31 | 0.31 |
| IND | Joseph Addai | addjo | 16 | 798 | 10 | 68 | 418 | 4 | 2 | 49.88 | 0.63 | 4.25 | 26.13 | 0.25 | 0.13 |
| JAX | Maurice Jones-Drew | jonma | 16 | 1474 | 20 | 60 | 396 | 2 | 2 | 92.13 | 1.25 | 3.75 | 24.75 | 0.13 | 0.13 |
| KCC | Jamaal Charles | chaja | 16 | 700 | 3 | 50 | 400 | 2 | 3 | 43.75 | 0.19 | 3.13 | 25.00 | 0.13 | 0.19 |
| MIA | Ronnie Brown | broro | 16 | 1132 | 14 | 24 | 164 | 2 | 2 | 70.75 | 0.88 | 1.50 | 10.25 | 0.13 | 0.13 |
| MIA | Ricky Williams | wilri | 16 | 912 | 12 | 32 | 376 | 2 | 2 | 57.00 | 0.75 | 2.00 | 23.50 | 0.13 | 0.13 |
| MIN | Adrian Peterson | petad | 16 | 1580 | 18 | 38 | 378 | 2 | 4 | 98.75 | 1.13 | 2.38 | 23.63 | 0.13 | 0.25 |
| MIN | Chester Taylor | taych | 16 | 500 | 2 | 48 | 418 | 2 | 2 | 31.25 | 0.13 | 3.00 | 26.13 | 0.13 | 0.13 |
| NEP | Kevin Faulk | fauke | 16 | 500 | 2 | 46 | 384 | 2 | 2 | 31.25 | 0.13 | 2.88 | 24.00 | 0.13 | 0.13 |
| NEP | Laurence Maroney | marla | 16 | 694 | 6 | 12 | 100 | 2 | 2 | 43.38 | 0.38 | 0.75 | 6.25 | 0.13 | 0.13 |
| NEP | Sammy Morris | morsa | 16 | 500 | 3 | 38 | 438 | 2 | 2 | 31.25 | 0.19 | 2.38 | 27.38 | 0.13 | 0.13 |
| NEP | Fred Taylor | tayfr | 16 | 684 | 2 | 20 | 121 | 2 | 2 | 42.75 | 0.13 | 1.25 | 7.56 | 0.13 | 0.13 |
| NOS | Mike Bell | belmi | 16 | 1091 | 5 | 10 | 100 | 2 | 5 | 68.19 | 0.31 | 0.63 | 6.25 | 0.13 | 0.31 |
| NOS | Reggie Bush | busre | 16 | 500 | 8 | 54 | 384 | 2 | 4 | 31.25 | 0.50 | 3.38 | 24.00 | 0.13 | 0.25 |
| NOS | Pierre Thomas | thopi | 16 | 1040 | 11 | 30 | 219 | 2 | 2 | 65.00 | 0.69 | 1.88 | 13.69 | 0.13 | 0.13 |
| NYG | Ahmad Bradshaw | braah | 16 | 916 | 7 | 18 | 171 | 2 | 2 | 57.25 | 0.44 | 1.13 | 10.69 | 0.13 | 0.13 |
| NYG | Brandon Jacobs | jacbr | 16 | 1097 | 4 | 18 | 100 | 2 | 2 | 68.56 | 0.25 | 1.13 | 6.25 | 0.13 | 0.13 |
| NYJ | Thomas Jones | jonth | 16 | 1408 | 14 | 12 | 100 | 2 | 2 | 88.00 | 0.88 | 0.75 | 6.25 | 0.13 | 0.13 |
| NYJ | Leon Washington | wasle | 16 | 754 | 2 | 34 | 299 | 2 | 2 | 47.13 | 0.13 | 2.13 | 18.69 | 0.13 | 0.13 |
| Team | Name | Symbol | Appearances | R Yds | R TDs | Rec | R Yds | R TD's | Fum L | R Yds | R TDs | Rec | R Yds | R TD's | Fum L |
| OAK | Justin Fargas | farju | 16 | 701 | 3 | 29 | 195 | 2 | 2 | 43.81 | 0.19 | 1.81 | 12.19 | 0.13 | 0.13 |
| OAK | Darren McFadden | mcfda | 16 | 614 | 5 | 36 | 351 | 2 | 2 | 38.38 | 0.31 | 2.25 | 21.94 | 0.13 | 0.13 |
| PHL | LeSean McCoy | mccol | 16 | 696 | 4 | 40 | 326 | 2 | 2 | 43.50 | 0.25 | 2.50 | 20.38 | 0.13 | 0.13 |
| PHL | Brian Westbrook | wesbr | 16 | 630 | 3 | 54 | 416 | 3 | 2 | 39.38 | 0.19 | 3.38 | 26.00 | 0.19 | 0.13 |
| PIT | Rashard Mendenhall | menra | 16 | 1146 | 8 | 18 | 156 | 2 | 4 | 71.63 | 0.50 | 1.13 | 9.75 | 0.13 | 0.25 |
| PIT | Mewelde Moore | moome | 16 | 500 | 2 | 28 | 200 | 2 | 2 | 31.25 | 0.13 | 1.75 | 12.50 | 0.13 | 0.13 |
| PIT | Willie Parker | parwi | 16 | 598 | 2 | 16 | 170 | 3 | 3 | 37.38 | 0.13 | 1.00 | 10.63 | 0.19 | 0.19 |
| SDC | Michael Bennett | benmi | 16 | 500 | 2 | 10 | 100 | 2 | 2 | 31.25 | 0.13 | 0.63 | 6.25 | 0.13 | 0.13 |
| SDC | Darren Sproles | sprda | 16 | 500 | 2 | 50 | 578 | 4 | 2 | 31.25 | 0.13 | 3.13 | 36.13 | 0.25 | 0.13 |
| SDC | LaDainian Tomlinson | tomla | 16 | 771 | 8 | 24 | 107 | 2 | 3 | 48.19 | 0.50 | 1.50 | 6.69 | 0.13 | 0.19 |
| SFO | Frank Gore | gorfr | 16 | 1192 | 13 | 59 | 507 | 3 | 2 | 74.50 | 0.81 | 3.69 | 31.69 | 0.19 | 0.13 |
| SEA | Edgerrin James | jamed | 16 | 500 | 2 | 10 | 100 | 2 | 2 | 31.25 | 0.13 | 0.63 | 6.25 | 0.13 | 0.13 |
| SEA | Julius Jones | jonju | 16 | 764 | 4 | 40 | 354 | 4 | 2 | 47.75 | 0.25 | 2.50 | 22.13 | 0.25 | 0.13 |
| STL | Steven Jackson | jacks | 16 | 1568 | 2 | 48 | 372 | 2 | 4 | 98.00 | 0.13 | 3.00 | 23.25 | 0.13 | 0.25 |
| TBB | Earnest Graham | graea | 16 | 901 | 6 | 37 | 278 | 2 | 2 | 56.31 | 0.38 | 2.31 | 17.38 | 0.13 | 0.13 |
| TBB | Derrick Ward | wardd | 16 | 500 | 2 | 23 | 229 | 2 | 2 | 31.25 | 0.13 | 1.44 | 14.31 | 0.13 | 0.13 |
| TBB | Carnell Williams | wilca | 16 | 722 | 4 | 34 | 234 | 2 | 2 | 45.13 | 0.25 | 2.13 | 14.63 | 0.13 | 0.13 |
| TEN | Chris Johnson | johch | 16 | 1918 | 12 | 42 | 324 | 2 | 2 | 119.88 | 0.75 | 2.63 | 20.25 | 0.13 | 0.13 |
| TEN | LenDale White | while | 16 | 500 | 2 | 10 | 100 | 2 | 2 | 31.25 | 0.13 | 0.63 | 6.25 | 0.13 | 0.13 |
| WSH | Ladell Betts | betla | 16 | 500 | 2 | 32 | 346 | 2 | 2 | 31.25 | 0.13 | 2.00 | 21.63 | 0.13 | 0.13 |
| WSH | Clinton Portis | porcl | 16 | 988 | 2 | 18 | 114 | 2 | 2 | 61.75 | 0.13 | 1.13 | 7.13 | 0.13 | 0.13 |
| Team | Name | Symbol | Appearances | R Yds | R TDs | Rec | R Yds | R TD's | Fum L | R Yds | R TDs | Rec | R Yds | R TD's | Fum L |